Antidiabetic Effects of Alcoholic extracts of Eryngium Billardieri and Mangifera Indica in Alloxan-Induced Diabetic Rats

Management of diabetes without side effects is still of great concern to medical practitioner. Medicinal herbs are used for the treatment of Diabetes mellitus worldwide. The present study investigated the anti-diabetic effects of Eryngium billardieri (EB) and Mangifera indica (MI) extracts on biochemical parameters in induced diabetic Wistar rat models. Alloxan monohydrate was used to induce diabetes in rats weighing 200- 250 g. The fasted diabetic rats were divided in to 4 groups of 5 animals each. The positive control group had received normal saline. The negative control group received only 110 mg/kg of alloxan monohydrate. Diabetic rats in groups 3 and 4 had received EB and MI extracts respectively. this study was conducted over a period of 21 days with oral administration of the plants extracts on the 3th day after alloxan treatment. All the test groups showed a reduction on blood glucose level, and the antidiabetic effect of EB was less than MI (EB:36%, MI:66.5%). The Insulin gene expression in pancreas was determined in all groups and the results showed that in treated groups with plants extracts the Ins expression was higher than in diabetic group. In conclusion, the results of the current study show that EB and MI extracts significantly reduce the serum glucose levels in alloxan-induced diabetic rats.

کلیدواژه ها:

Type 2 Alloxan monohydrate ، Diabetes mellitus ، Eryngium billardieri ، Mangifera indica.