miR-335: a novel biomarker in retinal disease

MicroRNAs as small noncoding RNAs play an important role in Regulation of gene expression. The expression of more than one third of human genes is regulated by miRNAs. Functional studies have shown that alternation in their expression level might underlies Human diseases. However, the role of microRNAs in retinal diseases has not been well studied. Here we used bioinformatics approach to predict the most important and also common miRNAs in retinal diseases. At first, groups of retinal diseases were studied. Interestingly, it turned out that three types of them including achromatopsia, Stargardt macular dystrophy and leber congenital amaurosis have common pathways. Bioinformatics databases were used to detect the genes involved in these types of retinal diseases and the pathways in which the genes were involve. Then , by studying the miRNA databases and examining the interaction of miRNA-mRNA, the microRNAs regulating the genes involved in these diseases were identified. In this study microRNA-335 is suggested as a candidate miRNA in retinal disease. Therefore, classifying important genes and their pathways provides a clear horizon for identifying the common miRNAs involved in these types of retinal diseases.

کلیدواژه ها:

Bioinformatics approach ، miRNA-335 ، Novel biomarker ، Retinal disease.