Circulating Endometriosis Related microRNA Relation with Metabolic Alteration

Endometriosis is clinically described as the growth of endometrial glands and stroma outside the uterus and inside the peritoneum cavity. This disease often leads to dysmenorrhea, dyspareunia, episodic abdominal pain, and bowel symptoms and sometimes it linked with symptoms unconnected to the reproductive tract, for instance, women with endometriosis have been shown frequently to have subordinate body mass index (BMI) than those without the disease. Although there is not enough information regarding the pathophysiology of this disease may be dysregulation of expressed genes can be the principal reason for these clinical symptoms. Regulations of expressed genes are related to circulating microRNA and are known to be differentially expressed in the sera of women with endometriosis compared to the healthy group. Here we sought to determine whether endometriosis-related differential miRNA expression could induce changes to normal adipocyte metabolic gene expression in women with endometriosis as well as stem cell content of fat tissue in mice model of endometriosis. These findings may explain the clinically-observed low body mass index of patients with endometriosis and contribute to our understanding of endometriosis as a complex and systemic disorder.

کلیدواژه ها:

endometriosis ، BMI ، microRNA ، fat ، stem cell