Combined Effects of p53 and PAI-1 polymorphisms on the Breast Cancer Susceptibility among Iranian-Azeri Women

سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 486

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شناسه ملی سند علمی:

CIGS15_122

تاریخ نمایه سازی: 13 بهمن 1398

چکیده مقاله:

Backgrounds and Objectives: Breast cancer is the main cause of death especially because of this cancer in women around the world. It is a heterogeneous and multifactorial disease. According to previous reports, polymorphism in two genes; p53, which is an important tumor suppressor gene involved in wide range of cancers, and PAI-1, which is an inhibitor protein coding plasminogen involved in progression and metastasis, has been investigated.Material and Methods: In this case-control study, 200 patients and 200 healthy women in Iranian-Azeri population were investigated. At first, genomic DNA had been extracted using high salt method, then these genes had been genotyped with tetra-ARMS PCR method. Data had been analyzed with javastat online statics package and SPSS (version 22.0). Results: Genotype distribution of these polymorphisms for p53 and PAI-1 was GG=43.5%, GC=42%, CC=14.5% and 4G/5G=70.5%, 5G/5G=18.5%, 4G/4G=11%, respectively. No association between allelic frequency and genotype, individually nor in combination have been shown. Also, there was no association between combined genotype with pathological properties of cancer.Conclusion: Our results show that polymorphism of codon 72 of p53 has a significant association with breast cancer (p value<0.023). Even though there was no association in combined genotype with breast cancer in our investigated population, further studies need to be done in bigger population and other races.

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نویسندگان

Nasser Pouladi,

PhD, Department of Biology, Faculty of Science, Azarbaijan Shahid Madani University, Tabriz, Iran

Mojtaba Shavali,

Department of Biology, Faculty of Science, Azarbaijan Shahid Madani University, Tabriz, Iran