Down-regulation of SNF-related kinase,(SNRK), in patients tissue samples with breast cancer

سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 400

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شناسه ملی سند علمی:

CIGS15_018

تاریخ نمایه سازی: 13 بهمن 1398

چکیده مقاله:

Introduction: Breast cancer is Known as one of the most salient and prevalent cancers among women and responsible for death in people, affected with this cancer. This study aims to investigate a coding protein called SNRK. Whose function is not well characterized. According to studies conducted, We have come to the conclusion that SNRK is a member of the sucrose non fermenting (SNF)-related kinase family of serine/threonine kinases, a ubiquitous expression in the bone marrow. As a mater of fact, this gene is generally known as cellular metabolism and adipocyte inflammation regulatory. SNRK has been studied in thin body of cancers, while it has Down-regulated in colon cancer.In this study, we have investigated expression changes of SNRK gene in clinical tissue samples of breast cancers for the first time.Methods: In the present study, clinical samples of breast cancer tissues were separately collected and SNRK expression levels were measured through total RNA isolation, cDNA synthesis and quantitative Real-Time PCR, in tumor tissue cells and their normal tissue margins. Data was statistically analyzed. Results: Our data analyses indicate that the expression level of SNRK gene is down-regulated in tumor cells compared to their normal tissue margins. Conclusion: In overall, this is the first report of SNRK in a cancer, especially in breast cancer. Based on the outcomes of the current research, SNRK may potentially considered as a tumor suppressor, but it corroboratuin requires further investigations.

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نویسندگان

shahrzad Fattai

Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran

mohammad shafiee

Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran- Department of Medical Genetics,Faculty of Advaced Medical Technologies, Golestan University of Medical Sciences, Gorgan, Iran

Bahramian bahramian

Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran

fatemeh t. shamsabadi

Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Golestan University of Medical Sciences, Gorgan, Iran.

abdolreza Fazel,

Cancer Research Center, Golestan University of Medical Sciences, Gorgan, Iran