Phytoremedies, a nature-based approach for skin wound healing

Skin injuries are one of the major global public health problems that can lead to considerable morbidity, including chronic wounds, infection, and scarring. Recognition of the value of traditional medicine and indigenous pharmacopoeia has led to increased application of various natural products including plant-derived extracts for wound healing and skin regeneration worldwide. Plant extracts possess antioxidant, anti-inflammatory, angiogenic, and cell synthesis-modulating components that are almost affect coagulation, inflammation, proliferation, formation and finally repair of skin fibrous tissues. The increasing evidences have been confirmed antimicrobial activity, free radical scavenging properties, stimulation of enhanced collagen production and/or angiogenesis promotion of medicinal plants with identification of lead scaffold chemical structures. Though natural plant products can be much cheaper than conventional treatments, concomitant administration of the plant extracts and conventional medicine such as antibiotics needs to be further investigated in wound management mainly due to the toxicity or possible interactions which could mimic, oppose or magnify the effect of the latter. Here, we briefly present up-to-date fundamental achievements, and discuss mechanism of action(s) of some of the phytochemicals to promote better understanding of the phytoremedies effects on regulation of skin regeneration both for health-care professionals and herbal consumers. These data shed light on the way of specific utilization of plant-based compounds according to the different types of wounds.

کلیدواژه ها:

Wound healing ، Alternative medicine ، Herbal extracts ، Skin care