Stem Cell from Human Exfoliated Deciduous Teeth as a novel source in wound healing

Background and Objectives: Wound healing is a complex biological process that affects multiple tissues type. The goal of regenerative medicine is to facilitate the rapid replacement of lost or damaged tissue with functional physiologic tissues similar to the previous one. Some researchers have investigated the use of SHEDs for repairing or regeneration of dental and non-dental tissues.In this systematic review, we focused on the ability of SHEDs as a new potential source for wound healing.Search method: Published articles were accomplished by PubMed, Google Scholar, Wiley, Springer, ScienceDirect, and Elsevier from 2008 to September 2018. Entirely, 16 articles were found and reviewed.Results: SHEDs are multipotent stem cells found in the pulp tissue of human exfoliated deciduous teeth. These are high proliferating and clonogenic stem cells that have the capacity of differentiating into several variations of cell types. SHEDs effect on wound healing was observed macroscopically and histologically. Also, scientists evaluated Hyaluronic acid (HA) level value. HA expression volume value was significantly higher in SHEDs and hMSCs. Epithelialization and thick connective tissue were accelerating information in 5-7 days versus the control group. SHEDs and human mesenchymal stem cells (hMSCs) accelerate wound healing.Conclusions: SHEDs are self-renewal, easily accessible, non-invasive that may have limiting ethical concerns. Showing significant results in researches introduces SHEDs as a novel stem cell source for cell therapy in wound healing in future decades.

کلیدواژه ها:

Stem cells from human exfoliated deciduous teeth ، tissue regeneration ، wound healing ، cell therapy.