Polymeric Micelles: Synthesis By Microfluidic Technique And Its Role In Dermatology Disorder

سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 341

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شناسه ملی سند علمی:

WTRMED06_127

تاریخ نمایه سازی: 5 بهمن 1398

چکیده مقاله:

Introduction: Among a variety of nanoscale drug delivery systems, Polymeric Micelles (PMs) have progressively attracted much consideration. One application of PMs is topical drug delivery to improve skin penetration and treatment of dermatological diseases. In the production of PMs, more control of process is crucial in order to produce nanomaterials with desired features, whilst there remain challenges in the most commonly used batch systems. The recent development in the field of microfluidic and lab-on-a-chip technologies has confirmed that microfluidic technique offers a series of advantages in terms of speed, controllability, integration, and automation. Microfluidic technique is a science of manipulating small volumes of fluids in microchannels. The current study aimed at reviewing the role of polymeric micelles on dermatological disorder that have been created by microfluidic technique.Method: In this review, English papers related to the microfluidics and polymeric micelles are searched in PubMed database without any published date restrictions. The description and advantages of microfluidic-based process’s development for the production of PMs with dermatological applications has been extracted from included papers.Results: Microfluidic technique has been studied and introduced as a useful platform for the production of PMs with improved controllability, reproducibility, and homogeneity of the size characteristics.Advantages of PMs as topical nanocarriers have been reported including drug solubilization enhancement into the skin, increasing of hydrophilic drug partitioning into the SC ( ), drug localization into the hair follicles and different layers of epidermis, and providing depot into the skin by slow drug release from polymeric micelles.Conclusion: Microfluidic reactors provide a useful platform for the production of polymeric micelles with improved controllability, reproducibility, and homogeneity of the size characteristics. The Polymeric micelles created with this technique are novel drug carriers that provide efficient drug delivery through skin for treatment of dermatological diseases such as psoriasis, acne, and burn.

نویسندگان

Mahnaz Ahmadi

Ph.D, student of Pharmaceutical nanotechnology, Shahid Beheshti University of Medical Science, Tehran, Iran