Nanotechnology Applications In Antimicrobial Wound Dressing

سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 324

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شناسه ملی سند علمی:

WTRMED06_125

تاریخ نمایه سازی: 5 بهمن 1398

چکیده مقاله:

The skin is the largest organ of the body. Wounds are described as disruptions in the normal anatomical structure of the tissue which lead to an abnormal behavior. Traumatic and chronic wounds are exposure to risk of infections. So wound dressings and devices form an important segment of the medical and pharmaceutical wound care market worldwide. Dressings are classified into inert/passive, bioactive (medicated) and interactive. Those are include gauzes, hydrocolloids, alginates, fibers, hydrogels, semi-permeable films and foams. Some wound dressings can play an important role to control infection, both as a physical barrier against invasive exogenous bacteria and as an antimicrobial delivery system for the treatment or prevention of infection.Compared to conventional wound care products, nanotechnology based therapies offer unique opportunities. Nanoparticles (for example Ag NPs) are considered as promising alternatives to conventional antibiotics, because they exhibit antibacterial activity against a large number of strains and are capable of reducing adverse drug side effects. And do not stimulate microbial resistance. NPs are also capable of carrying, protecting, and sustaining the release of fragile and sensitive drugs in vivo.Dressings with nanostructure such as nanofibrous are used to form synthetic ECM.Several intrinsic properties of nanofiber scaffolds, including high surface area to volume ratio, sufficient mechanical stability and sufficient pore size of the resulting nanofibrous matrix, make them attractive for wound healing and drug delivery applications.Wound dressings with Antimicrobial effects generate from Antimicrobial materials such as chitosan, Antimicrobial agents incorporated in dressing (hydrogels) and Antimicrobial agents loaded in nanocarrier incorporated in wound dressing (liposomal hydrogels). The development of dressings containing antibacterial substances can provide several advantages in terms of prolonged topical antibacterial release, reduced toxicity, adverse effects and reduced antibiotic resistance. When the antibiotics are incorporated in the matrix there is a strong burst release in the first few hours. The main purpose of enter of nanocarriers into wound dressings such as hydrogel was to control drug release and to stabilize the carrier structure by creating a protective film on the vesicle surfaces. The application of nanoparticles and nano carriers offer a good chance to treat and control of post wound infections.

نویسندگان

Zahra Nazemoroaya

PHD, student of pharmaceutical nanotechnology, shahid beheshti medical university, tehran, Iran