Fabrication of Thick Scaffold with Microfluidic Channels by Bio-printer

سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 558

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شناسه ملی سند علمی:

WTRMED06_095

تاریخ نمایه سازی: 5 بهمن 1398

چکیده مقاله:

Although cardiovascular diseases are among the leading causes of death all around the world, currently, there is no way to regenerate the damaged tissue in the clinic, and the only approved method being used for acute heart failure treatment is heart transplantation which is limited by the lack of matching and sufficient donors. The most significant challenge which is preventing experimental methods to get into the clinical fields is that there is no acceptable way to deliver enough cells and preserve them in the heart muscle to reconstruct a healthy tissue. Cardiac patches were introduced to solve such problems, but, until now, because of diffusion limitation of nutrient and oxygen and low speed of natural angiogenesis process which both result in the necrotic core formation, they were not successful. In this project, the ultimate goal is to fabricate a thick scaffold which could support heart function in which there are microfluidic channels created with a dual-nozzle extrusion-based bio-printer and sacrificial materials to facilitate nutrient diffusion in the scaffold. Partially oxidized alginate and gelatin are the biomaterials used for testing printability, porosity and channels’ shape, and mechanical properties. After examining various concentrations for the printability, the proper ones were selected for the channels formation and tensile modules experiments. Afterwards, the cell viability will be measured, and the effects of channels’ existence will be evaluated. In conclusion, according to the tests’ results, we hope that this method could get us one step closer to the ideal treatment for the replacement and regeneration of damaged cardiac tissue.

نویسندگان

Sadaf Khalighi

MSc, student of biomedical engineering, Sharif university of technology, Tehran, Iran