Platelet-Rich Plasma (PRP) and Healing of Acute and Chronic Wounds: Experiences of Our Performed Clinical Trials

Introduction: Wounds are divided into the two main categories according to their time of incidence: acute and chronic. Both those facing different complications meeting various types of morbidities which causes a notable expense to the health care system and society. Platelet-rich plasma (PRP) mostly uses in the autologous form in different intervention including for acute and chronic (non-healing) wounds. Methods: Our team has performed trials on the potential of this this product on healing of acute and chronic (non-healing) wounds. In the acute wounds pilonidal sinus wounds with secondary intention healing (randomized clinical trial: 55 patients and 55 controls) and for the chronic wounds diabetic foot ulcers or DFU (single arm clinical trial) chose as the target. Results: In the pilonidal trial, it was showed that the gel formation is the best form the PRP but after an intra-operative injection course of PRP. The results revealed that healing of wound were higher in the treatment arm than standard care dressing group (3.3±0.64 vs 6.5±1.03 weeks, P<0.001). Moreover, we have showed that the patients of treatment group experienced a shorter period of disability and pain and infection were lower in the treatment group than controls (all P<0.001). Interestingly, we have showed that angiogenesis derived wound healing in the treatment arm (P<0.001). Also, results of our single arm trial regarding effectiveness of PRP therapy on diabetic foot ulcers 70 cases (71 ulcers) with chronic non-healing DFU were treated with weekly topical application of PRP. The mean size and duration of wounds were 6.11 cm2 and 19.71 weeks respectively. It was showed that wound area was significantly decreased 59.1% in the first 4 weeks of treatment (CI: 46.7–57.1). All the wounds who did not left the study healed completely in average of 8.7±3.93 weeks without any treatment related complications. Conclusion: The performed trials showed that PRP therapy is a safe and useful treatment option for treatment of both acute and chronic wounds. Also, despite of being an autologous product, it is much cheaper than other similar allogenic options such as human amnion/chorion membrane.

کلیدواژه ها:

Platelet-rich plasma ، Diabetic foot ulcer ، Pilonidal disease ، Angiogenesis