Pistacia Atlantica resin oil accelerates wound healing process : A Systematic Review

Background & Objective: Considering the antioxidant properties of The pistacia atlantica resin oil (Mastic resin Oil), it is used for the treatment of a variety of wound inflammations including burn wound and diabetic foot in iranian traditional medicine. it has also been reported mastic oil has antimicrobial effect on skin lesions.This study was conducted to evaluate the effect of Mastic resin oil and its potential benefits on acceleration of wound healing process .Methods: In this review study Pubmed, Science Direct, web of science and MagIran were searched for studies published between 2010 and 2019 with the following mesh terms: mastic tree, P.Atlantica, mastic resin, wound, burn, diabetic foot, inflammation. Articles were limited to journals published in English language. Identifying against inclusion criteria (full text accessibility and link to the topic) and exclusion criteria (full text inaccessibility), the articles were appraised independently by two reviwers. 15 studies met all the inclusion criteria and were selected for this systematic review.Results: In 5 RCTs, mastic resin oil significantly increased antioxidant defense, vasculoendothelial growth factor and hydroxyprolin in the intervention group and also reduced malondialdehyde levels and burn wound size. To some extent, it showed more benefits than sulfadiazine. The findings of animal studies showed mastic resin oil increased wound contraction percentage and upregulated hydroxyprolin content. The animals treated with medium to high doses of mastic oil exhibited remarkably higher fibroblast distribution and significantly lower immune cells infiltration in wound area. It elevated neovascularization in a dose dependent manner. In a study evaluating matic resin oil on episotomy pain, it showed higher healing rates of wound in intervention group. Studies using mastic resin oil on diabetic foot wound indicated that it inhibits the growth of some groups of bacteria in diabetic foot ulcers and hence reduces the recovery time and hospital stay. P.atlantica oil has anti-QS activities and may have the potential for treatment of chronic infections caused by Pseudomonas aeruginosa. Conclusion: Pistacia atlantica resin oil has a concentration-dependent effect on the healing of various wound inflammations mainly by increasing the concentration of bFGF and PDGF, improving the angiogenesis and inhibiting the growth of some types of bacteria. P. atlantica resin oil could be considered as a new therapeutic agent for treatment of injuries.

کلیدواژه ها:

Pistacia Atlantica ، mastic resin oil ، wound healing ، inflammation