New generation of smart bandage chitosan-gelatin/AgO-NP using freeze drying technology for bedsore application

One of the sensors widely used as wound controller for smart wound monitoring is temperature and concentration changes sensor. Temperature measurement can provide information on local blood flow, wound aging, infection, as well as the correlation between increased temperature, increased angiogenesis and thickening of the tissue or the relationship between wound healing rate and temperature. Therefore, the analysis indicates the level of inflammation or infection using smart bandage. There are various methods for fabricating scaffolds in tissue engineering such as freeze-drying (FD) and electro-spinning (ELS), in which the biomaterials are combined with each other with addition of acetic acid. Then, frozen and subsequently obtained samples can produce the moisture contained in the porosity. The presence of cavities in the scaffold causes stress concentration in the area and decreases proper mechanical strength can be achieve, however, proper porosity is required for cell adhesion and tissue growth. The bio-nanocomposites wound tissue made by FD is characterized by the above-mentioned experiments such as scanning electron microscopy (SEM) and biological properties analysis. The specimen made with the temperature, humidity, message module and control board that can be set a proper program was assigned to detect critical condition of the wound and send the message to the doctor. In order to fabricate the novel smart bio-nanocomposite various biopolymer were used such as chitosan, alginate, silver oxide and gelatin as well as temperature and humidity sensors, GSM module and control board in which discussed later. After that, the method of project including method and percentage of material composition and manufacturing method is described. The optimum sample has conductive filaments in the center of wound bandage to generate heat and having a temperature-sensitive hydrogel surrounded by a layer containing various drugs and a control board. This dressing is tailored to the patient s needs with specific heating to the central filament, hydrogels, which release different amounts of drug due to different temperatures, releasing the drug to the wound cite.

کلیدواژه ها:

Smart Wound ، GSM Module ، Freeze Drying ، Tissue Engineering