The role of serotonergic system in anticonvulsant effects of deep brain stimulation

Background and Aim : The mechanisms of deep brain stimulation (DBS) for epilepsy or movement disorders remain incompletely understood. The synaptic terminal may independently influence by DBS. There are some evidence supports the possibility that serotonergic pathways and 5-HT1 are involved in seizure modulation by DBS.Methods : Amygdala kindling was conducted in a semi-rapid kindling stimulations (12 stimulations per day) in male Wistar rats. Low Frequency Stimulation (LFS, 0.1 ms pulse duration at 1 Hz, 200 pulses, 50–150 μA, 5 min) was applied after termination of kindling stimulations. NAD-299 (a selective 5-HT1A receptor antagonist; 2.5 and 5 μg/μl) was microinjected into the hippocampal CA1 before applying LFS.Results : Application of LFS following daily kindling stimulations reduced the behavioral seizure stages, afterdischarge duration, and stage 5 seizure duration and increased the latency to stage 4 seizure compare to the kindled group. However, Microinjection of NAD at the doses of 5 μg/1μl but not 2.5 μg/1μl blocked the inhibitory effect of LFS on behavioral and electrophysiological parameters in kindled animals.Conclusion : There are some connections between serotonin and other neuromodulators actively involved in DBS anti-seizure effects which interactions and probable mechanisms has been discussed.

کلیدواژه ها:

Serotonin ، Deep brain stimulation ، Kindling