Investigation of the therapeutic effect of nicotine and its metabolite on the brain

سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 334

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شناسه ملی سند علمی:

NSCMED08_100

تاریخ نمایه سازی: 15 دی 1398

چکیده مقاله:

Background and Aim : nicotine is a stimulant and potent parasympathomimetic alkaloid that is extracted from tobacco . Nicotine acts as a receptor agonist at most nicotinic acetylcholine receptors (nAChRs) .Except at two nicotinic receptor subunits (nAChRα9 and nAChRα10) where it acts as a receptor antagonistMethods : Nicotine constitutes approximately 0.6–3.0% of the dry weight of tobacco. Usually consistent concentrations of nicotine varying from 2–7 μg/kg are found in the edible family Solanaceae, such as potatoes, tomatoes, and eggplantResults : Nicotine is highly addictive. It is one of the most commonly abused drugs. An average cigarette yields about 2 mg of absorbed nicotine; high amounts can be more harmful. Nicotine addiction involves drug-reinforced behavior, compulsive use, and relapse following abstinence. Nicotine dependence involves tolerance, sensitization, physical dependence, and psychological dependenceConclusion : Nicotine induces both behavioral stimulation and anxiety in animals. Research into nicotine s most predominant metabolite, cotinine, suggests that some of nicotine s psychoactive effects are mediated by cotinine.Cotinine has been shown to be psychoactive in humans and animals, facilitating memory, cognition, administrative function, and emotional responding. Furthermore, recent research shows that cotinine acts as an antidepressant .Nicotine activates nicotinic receptors (particularly α4β2 nicotinic receptors) on neurons that innervate the ventral tegmental area and within the mesolimbic pathway where it cause the release of dopamine.

کلیدواژه ها:

cotinine. nicotine. memory.acetylcholin receptor. Memory

نویسندگان

Amin Ataie

babol university of medical science, department of pharmacology