INVESTIGATION OF THE EFFECTIVENESS OF INTRALIPID ADMINISTRATION IN PATIENTS WITH TRAMADOL POISONING AND LOSS OF CONSCIOUSNESS

سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 354

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شناسه ملی سند علمی:

KAMED13_329

تاریخ نمایه سازی: 10 دی 1398

چکیده مقاله:

Background and Aim : We investigated short and long term effects of intralipid administration in cases with tramadol poisoning at a referral poisoning center in Tehran, Iran.Methods : In this clinical trial, 60 patients with pure tramadol poisoning, GCS<12 and older than 16 years were selected by convenience sampling and randomly assigned to intervention and control groups. The intervention group received 1000cc of Intralipid 30% after admission and stabilization. Vital signs and GCS in both groups were recorded twice: firstly, at admission and secondly 3 hours after infusion of Intralipid in the intervention group and 12 hours after admission in controls. Vital signs, GCS, hospitalization duration and rate of seizure occurrence were compared between two groups. SPSS16 was used for statistical analysis and statistically significant level was considered <0.05. Results : Mean (SD) age of participants was 24.42 (7.98) years and 42 (70%) were male. Both groups were similar in age, gender, ingested dose of tramadol, vital signs and GCS at admission. Compared to controls, patients after administration of Intralipid showed lower mean systolic (p=0.04) and diastolic (0=0.03) blood pressures and greater mean GCS (p=0.03). In addition, mean days of hospitalization and rate of seizure occurrence were both lower in the intervention group (p=0.04 and <0.001, respectively). All patients discharged in good condition. Conclusion : We found promising short and long term effects of Intralipid infusion in the management of patients with tramadol poisoning and loss of consciousness but due to good prognosis of such patients, cost effectiveness of this treatment should also be considered.

نویسندگان

Behnam Behnoush

Department of Forensic Medicine and Toxicology, Tehran University of Medical Sciences, Tehran, Iran

Negar Khoshnevis

Legal Medicine Research Center, Legal Medicine Organization, Tehran, Iran

Mohammad Arefi

Department of Forensic Medicine and Toxicology, Tehran University of Medical Sciences, Tehran, Iran

Fardin Fallah

Legal Medicine Research Center, Legal Medicine Organization, Tehran, Iran