BEHAVIORAL ASPECT OF MPFC, PRH AND HIPPOCAMPAL FUNCTIONAL CONNECTIVITY OF CANNABINOID SYSTEMS ON METHAMPHETAMINE-INDUCED OBJECT RECOGNITION MEMORY IMPAIRMENT

Background and Aim : Methamphetamine (METH) is one of the most powerful psychostimulant that leads to long lasting neuropsychiatric deficits including memory impairments after the cessation of abuse. On the other hand, CB1 receptors have been reported to interfere with a diverse range of cognitive functions including learning/memory and are highly expressed in the hippocampus, medial prefrontal cortex (mPFC) and perirhinal cortex (PRH), the regions of the brain which believed to have an important function in certain forms of learning and memory. In light of intimate interactions between cannabinoid system cannabinoid and recognition memory, the present study examined the effect of WIN55212-2 cannabinoid CB1 receptors agonism on methamphetamine-induced object recognition memory impairmentMethods : For this purpose, a new computation method is presented and applied with using a series of behavioral tests: a novel object preference task, an object-in-place task, and a temporal order memory task in male Wistar rats. Results : The findings showed that the novel object preference task, object-in-place and temporal order memory tasks were significantly impaired in METH (2mg/kg s.c.) group in comparison with saline group. Administration of a single intra hippocampal, mPFC, PRH , injection of the CB1 receptor agonist, WIN 55,212-2 (‘WIN’), at 0.1 g/rat can partially improve cognitive performance in METH-Exposed animals in behavioral and computational model. However, No group was impaired in the object location task. Conclusion : Taken together, these results provide direct support for the hypothesis that cannabionied system in hippocampal, mPFC and PRH has a functional connectivity in modulation of destructive effects on psystimulant such as methamphetamine on neural network model for recognition memory.

کلیدواژه ها:

Methamphetamine ، Cannabionid ، Recognition memory