HTLV-1: ancient virus, new challenges

سال انتشار: 1393
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 451

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شناسه ملی سند علمی:

JR_RCM-1-3_009

تاریخ نمایه سازی: 2 دی 1398

چکیده مقاله:

Human T-lymphotropic virus (HTLV-1)  is an ancient pathogen for human being but arising and recognized recently. The routes of transmission are vertical (mainly by breastfeeding), unsafe sexual contacts and through contaminated blood components specially in whom need frequent and repeated blood transfusions such as permanent anemia due to blood loss in hemophilia and major thalassemia. Patients who should undergo hemodialysis in their lifelong are another instance for increased risk of HTLV-1 exposure. The main HTLV-1-associated diseases are tropical spastic tetraparesis (HAM/TSP), an inflammatory myelopathy and adult T-cell leukemia (ATL). Although HTLV-1 is scattered around the world, only in endemic areas where prevalence rate is more than 1%, viral burden of infection have accumulated. Japan, Southern and Central parts of Africa, Caribbean basin and Iran are examples of endemic areas of HTLV-1. In this article, a rapid and brief review of HTLV-1 virology, immunology and pathogenesis have emerged. In addition, a short debate has driven about current statues of HTLV-1 in Iran.

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نویسندگان

Marzieh Rahimzadegan

Department of Infectious Diseases, Imam Reza Hospital, Mashhad University of Medical Science, Mashhad, Iran.

Farshid Abedi

Department of infectious diseases, Imam reza hospital, Mashhad university of Medical science, Mashhad, Iran.

Seyed Abodolrahim Rezaei

Department of immunology, Ghaem hospital, Mashhad university of Medical science, Mashhad, Iran

Reza Ghadimi

Department of Cardiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

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