Prognostic Significance of Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography in Anal Squamous Cell Carcinoma A Systematic Review and a Meta-Analysis

Purpose: Prognostic significance of Fluorine-18 Fluorodeoxyglucose positron emission tomography (18F-FDG-PET) in anal squamous cell carcinoma (SCC) has been evaluated in several studies; however, the results seem to be controversial and no consensus exists about its predictive capability. The current meta-analysis was carried out to comprehensively investigate the prognostic significance of 18F-FDG-PET parameters in patients with anal SCC.Methods: A comprehensive literature search of PubMed/MEDLINE and Scopus databases was performed to retrieve pertinent articles published until August 5th 2018, concerning the prognostic significance of 18F-FDG-PET in patients with anal SCC. No language restriction was used. Several prognostic factors were reported for progression-free survival (PFS) and overall survival (OS) including pretreatment maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), inguinal nodal uptake, and metabolic response to therapy.Results: Eleven studies (741 patients) were included. The pooled hazard ratio (HR) for the probability of PFS were 5.36 [95% confidence interval (95%CI): 3.12-9.21, p<0.001] for metabolic response to therapy and 1.98 [95%CI: 1.26-3.12, p=0.003] for SUVmax. The pooled HR for the probability of OS was 5.87 [3.02-11.39, p<0.0001] for metabolic response to therapy. On the other hand, the study revealed that the pooled HRs of MTV and inguinal nodal uptake for PFS were 1.56 [95%CI: 0.96-2.53, p=0.072] and 1.79 [95%CI: 1-3.21, p=0.051], respectivelyConclusions: Our findings propose that 18F-FDG-PET parameters could serve as prognostic indicators in anal SCC

کلیدواژه ها:

18F-FDG PET ، Prognosis ، Anal cancer ، SUVmax ، Systematic review ، Meta-analysis ، MTV