Effect of topical Maggot therapy without injection of glucantime in treatment of cutaneous leishmaniasis

سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 360

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شناسه ملی سند علمی:

DCME02_199

تاریخ نمایه سازی: 19 آذر 1398

چکیده مقاله:

Background: Treatment of cutaneous leishmaniasis (CL) is directed toward eradication of amastigotes and reduction of the size of the lesions to promote healing with minimal scarring. Therapeutic failure in treatment of cutaneous leishmaniasis occurs in some of patients infected by Leishmania spp. In terms of developing effective treatments against leishmaniasis in endemic areas, it is important to think of comprehensive strategies that could cause a quick decrease in the pool of infected patients. Maggot therapy is the use of sterile myiasis fly larvae in skin and soft tissue wound treatments. Larvae dissolve and disinfect dead tissue on the wound with enzymes. This method is also called Larval Debridement Therapy (LDT) (Arrivillaga et al., 2008; Polat and Kutlubay, 2014; Sanei-Dehkordi et al., 2016).Objectives: The present article reports 3 cases of cutaneous leishmaniasis with chronic wound without used conventional therapies. This study evaluates the use of maggot therapy to treat chronic wounds cases of CL.Materials and Methods: 3 patients with lesions on their arm, on hands and finger who had not received any therapeutic modalities selected. The clinical diagnosis was verified by demonstration of amastigotes in direct smears from the lesions. Instead of systemic therapy the patients were treated by serial maggot therapy and followed daily.Results: In this study, 3 patients that had cutaneous leishmaniasis were treated with serial LDT and Amniotic membrane graft and complete healing was observed in the all patients after 45 days.Conclusion: The present report represents the first clinical demonstration of maggot therapy on cutaneous parasitic infections in Shiraz city. Also our experience with use of maggot therapy in the treatment of suppurative disease of soft tissues were successful. These results potentially validate effective Larval therapy treatment against cutaneous leishmaniasis aimed at using widespread it with humans in the future.

نویسندگان

Mohammad Reza Hashempoor

Social Security Organization, Shohada hospital, ER Department, Kermanshah, Iran

Seyed Hossein Malekpour

PhD student of Parasitology, Department of Pathobiology, Shiraz University, Shiraz, Iran.