MicroRNAs are Promising Tool for Early Diagnosis and Treatment of Multiple Sclerosis

سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 403

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شناسه ملی سند علمی:

MSC16_023

تاریخ نمایه سازی: 11 آذر 1398

چکیده مقاله:

Multiple sclerosis (MS) is a chronic autoimmune disease in which immune cells act against the myelin sheath, resulting in central nervous system (CNS) damage. It has been shown that miRNAs play an important role in the pathogenesis of MS. These regulatory molecules lead to the activation of different signaling pathways, regulation of several transcriptional factors, influencing the differentiation of Th17 cells, development of Tregs and alteration from Th2 to Th1 response in MS.MethodBased on our literature review from Scopus, Sciences direct, NCBI database, about 250 paper was collected eventually 150 paper was reviewed which was near for our aim of the study.ResultThe prediction of onset of disease and its progression remains one of the biggest challenges in managing MS patients. miRNAs could have considerable clinical relevance for the monitoring and prognosis of MS patients. Studies have revealed that dysregulation of miRNAs may initiate abnormal immune responses leading consequently in the emergence of autoimmunity. In this research, we have discussed the altered expression of miRNAs in MS patients.ConclusionOverall, circulating miRNAs could be valuable not only in understanding pathogenic mechanisms in MS but may also serve as diagnostic and prognostic biomarkers as well as in treatment approach. moreover, with developing technologies it has become easier to evaluate a whole profile of sncRNAs, which will significantly improve their predictive power.

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نویسندگان

Hanieh Beyrampour-Basmenj

Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran

Abbas Ebrahimi-Kalan

Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Mohammad Rahmatiyamchi

Department of Clinical Biochemistry and Laboratory Medicine, Division of Medical Biotechnology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

Rostam Rezaeian

Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran