Investigation of rs7501939 of HNF1B Gene with the Risk of T2DM in Prostate Cancer Patients

Introduction: Prostate cancer (PCa) is the second most common cancer among men worldwide. Many studies showed that men with PCa have a lower risk of T2DM than non-affected PCa patients. Genetic factors could play an important role to find a link between these two diseases. Common allelic variants in the HNF1B gene are associated with both T2DM and PCa. In this study, we investigated the association analysis of HNF1B rs7501939 with risk of T2DM in PCa patients.Materials & Methods: This case-control study contains 87 subjects who divided into six groups; Patients only with T2DM (n=14), Normal healthy subjects without history of T2DM and PCa (n=14), Benign prostate hyperplasia (BPH) subjects without history of T2DM (n=16), BPH subjects with T2DM (n=14), Radical prostatectomy (RP) subjects without history of T2DM (n=14) and RP subjects with T2DM (n=15). Blood samples were collected and the genotypes were determined by PCR-restriction fragment length polymorphism (PCR-RFLP) method.Results: We found no significant association between the frequency of rs7501939 C> T and the risk of T2DM in all subject groups.Conclusion: We found that the presence of the homozygous TT genotype is not associated with T2DM. The HNF1B gene variant could not play an important role in the risk of T2DM in a group of Iranian prostate cancer patients. Further investigations with larger sample size should be carried out to detect the exact effects of such genetic factor on developing T2DM in prostate cancer patients.