Comparative Study of Phenotypic Aspects of Type 2 Diabetes and MODY on a Population of Diabetic Ppatients in Isfahan Province

سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 540

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شناسه ملی سند علمی:

ICEMU05_049

تاریخ نمایه سازی: 9 آذر 1398

چکیده مقاله:

Introduction: Maturity-onset diabetes of the young (MODY) is a heterogeneous group of disorders with mutations in at least fourteen different genes leading to defect in insulin secretion. It is frequently mistakenly diagnosed as either type 1 or type 2 diabetes (especially T2D), but patiants with each types of diabetes have distinct and recognizable clinical symptoms.Materials & Methods: We conducted an analytical descriptive study on 120 diabetic patients (40 cases with T1D, 40 with T2D and 40 MODY patients) with the incidence of the disease before 25 years. Clinical features were evaluated in all the patients after determining the exact type of diabetes with specific markers (pancreatic antibodies and C-peptide) and compared in 3 major groups of diabetes. The age of onset, body mass index, HbA1C and dyslipidemia were examined in all these patients. All the markers were compared with 40 non-diabetic healthy control cases.Results: Average mean of age of onset in MODY patients is less than T2D, but more than T1D patients. The body mass index of T2DM was significantly higher compared with all MODY patients and T1D cases. HbA1C in MODY patients was within the normal range or a little high (less than 7.5%), but high in all the T2D and higher in T1D cases. Dyslipidemia is common in MODY patients, but less frequent compare to T2D cases.Conclusion: In recent years, researchers are try to find inexpensive and widely available biomarkers that are sensitive and specific to distinguish different types of diabetes to get the best treatment approach.

نویسندگان

Akram Sarmadi

Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran

Mohammad Amin Tabatabaiefar

Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. ۳Pediatric Inherited Diseases Research Center, Research Institute for Primordial Prevention of Noncommunicable Disease, Isfahan Univer

Fatemeh Tabatabaei

Isfahan Endocrine and Metabolism Reaserch Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Morteza Hashemzadeh Chaleshtori

Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran