Headspace single drop microextraction based on deep eutectic solvent for extraction of triazole pesticides in water samples by gas chromatography

In the present work, a new class of solvents in the name of deep eutectic solvent were prepared and used as an extraction solvent in a headspace single drop microextraction method for the preconcentration and extraction of triazole pesticides from real sample by gas chromatography method. Three different deep eutectic solvents were prepared by a mixing of choline chloride as a hydrogen bond acceptor and 4-chlorophenol, ethylene glycol and phenol as a hydrogen bond donor. The significant parameters in headspace solvent microextraction process such as type of solvent, drop volume, stirring speed, extraction temperature, extraction time and pH were optimized. Synthesized Choline chloride: 4-chlorophenol deep eutectic solvent is the highest extraction efficiencies for the target analytes among the tested deep eutectic solvents. The limit of detection calculated between 0.01 and 100 mgL-1 with the relative standard deviation ranging from 3.9 to 6.2. In the optimum conditions suggested headspace solvent microextraction was successfully used for the determination of triazole pesticides in vegetables and fruit juice samples.