Relationship Between SHBG Gene C458K Polymorphism and Breast Cancer Incidence in Urmia Women

Breast cancer as the most common type of cancer among women worldwide SHBG gene is a glycoprotein that binds to androgen and estrogen and sex steroids. This gene is located on the short arm of chromosome 3 (17 P12-13) and contains 2 exons. Be it. One of the most common mutations in this gene is C458K polymorphism, which converts aspartate amino acid to aspartate, which disrupts cellular control process. The purpose of this study was to investigate the association of SHBG gene C458K polymorphism with breast cancer in women.Materials and Methods: In this study, 5 women with breast cancer as control group were selected from 5 women as healthy group in West Azarbaijan province. RFLP and shear enzyme techniques were used for sequencing and data were analyzed by SPSS V.24 software.Results: Frequency of C allele was 69.19% in patients group and 82.68% in control group which showed a significant relationship with disease incidence (P = 0.02). Frequency of dominant homozygous (CC) genotype in patients was 62/01 (P = 0.04) indicating significant association with disease incidence while heterozygous (TC) and recessive homozygous (TT) genotypes. With 25.54% and 12.45% respectively, there was no significant relationship (P <0.05). Also, the incidence of disease was 28% in women with familial marriage (P = 0.05). (CL = 1.14-3.52-OR = 95%)Conclusion:Based on the results of the mutation of the SHBG gene C458K polymorphism, it is possible to disrupt the cellular control process, which can be used as a prognostic factor.