Relationship Between Serum Interferon Gamma Level and CD8 and NK Immune Cells in women with Metastatic Breast Cancer in Urmia

Breast cancer is the most common type of cancer among women worldwide. Interferon-gamma is a type of protein that host cells release in response to a pathogenic invasion that stimulates the immune system. NK cells are also part of the immune system s lymphocytes that target cancer-infected cells. Serum levels of interferon-gamma and CD8 and NK immune cells in women with metastatic breast cancer Materials and Methods: Our study population consisted of 5 patients with metastatic breast cancer and 5 women as control group. Serum levels of cytokines by ELISA and percentage of cells by flow cytometry using double antibodies Colors were determined against CD8 and CD3 / CD16 markers. The data were analyzed using SPSS V.24 and Anova test.Results: Serum levels of interferon-gamma in the patient group were equal to (0.24), which was significantly increased compared to the control group (P = 0.04) (CL = 1.19-3.71-OR = 95% Also CD4 lymphocyte percentage in blood Peripheral group of patients was equal to (0.22) which had a significant relationship with disease incidence (P = 0.05) (CL = 1.22-3.95-OR = 95%) but NK cell level was significantly different from group No control (P> 0.007).Conclusion: Based on the obtained results, interferon-gamma and CD8 cells have a significant relationship with the incidence of the disease, which can be used as prenatal factors.