Plasma Adiponectin in Polycystic Ovary Syndrome Is Connected with Recurrent Miscarriage and Obesity

Background: Polycystic ovary syndrome (PCOS) is a current endocrine disease that is connected with recurrent miscarriage (RM). many studies that have surveyed the outbreak of PCOS in RM. PCOS seems to be nearly linked to obesity. Several studies have recommended that, in women with PCOS, a surged body mass index (BMI) is connected with a hazard of RM. The mechanism of miscarriage in PCOS is that, a surged in blood flow insistence in the uterine arteries and a decrease in endometrial vessels have been discovered in young non-pregnant women with PCOS that could disable implantation and placentation. Changes in placentation could appear owing to low-grade chronic inflammation, which could trigger abnormal immune adjustment in implantation. Furthermore, adipose tissue contribution to obesity. Adipokine might play a critical role in embryo implantation. Adiponectin is the most plentiful plasma adipokine. Diseases connected with atypical adiponectin levels are PCOS, obesity, all of which are connected with fertility. obesity is connected with decreased plasma adiponectin levels in PCOS that surged hazard of miscarriage.Method: This is a brief review of recent literature on the status research networks such as Google Scholar, PubMed to identify plasma adiponectin in PCOS and connection between RM and obesity.Result: Thus, in women with PCOS, increases obesity and decreased adiponectin level that is connected with a hazard of RM.Conclusion: Studies have shown that abundant factors lead to obesity and RM associated with PCOS such as reduced in plasma adiponectin level. These data recommend that adiponectin is necessary for normal fertility. Finally, women with RM, obesity and PCOS also encounter infertility and, in such a condition drug’s treatment such as metformin, recombinant adiponectin therapy and surgery bariatric is helpful

کلیدواژه ها:

Polycystic ovary syndrome ، Obesity ، adiponectin ، recurrent miscarriage