The Impact of Iron Overload on pregnancy outcome: Implications for Preeclampsia

سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 380

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شناسه ملی سند علمی:

COBGY15_117

تاریخ نمایه سازی: 11 آبان 1398

چکیده مقاله:

Introduction: Iron is an essential element for the survival of most organisms, including humans. Demand for iron increases significantly during pregnancy to support growth and development of the fetus. Paradoxically, epidemiologic studies have shown that excessive iron intake and/or high iron status can be detrimental to pregnancy and is associated with reproductive disorders ranging from endometriosis to preeclampsia.Material and Method : The aim of this review is to discuss about the Impact of Iron Overload on Reproductive Disorders in Humans by using electronic databases PubMed, Cochrane, Embase, ProQuest and Science Direct from 2011 to present. Result:Many epidemiologic studies have shown that excessive iron intake and/or high iron status can be detrimental to pregnancy and is associated with the development of a number of reproductive disorders. This is due to an underlying ferroptopathy characterized by intracellular iron excess leading to ferroptosis, a process of programmed cell death mediated by iron-dependent lipid peroxidation of cell membranes. Ferroptosis has been shown to play an important role in sterile inflammatory conditions such as hypoxia/reperfusion injury. By way of illustration, some pregnancies generate an exaggerated response to the acute surge in oxygen and iron caused by the physiologic hypoxia/reperfusion event that occurs in all pregnancies at 8–10 weeks of gestation. This surge of oxygen and iron results in excessive membrane lipid peroxidation and ferroptosis at the maternal-fetal interface, primarily in trophoblast cells, leading to shallow endovascular invasion of EVCTs and suboptimal remodeling of the maternal spiral arteries, the pathologic hallmarks of PE. Conclusion: For clinical care providers, oral iron supplementation for the treatment of iron-deficiency anemia is considered effective, inexpensive, and safe in pregnancy. In non-anemic pregnant patients, however, routine iron supplementation is likely unnecessary and, if recommended, should probably be limited to less than 60 mg daily or every other day

نویسندگان

Somayeh Fallah

MSc of Midwifery Faculty Member of Nursing and Midwifery school, Qazvin University of Medical Science, Qazvin, Iran

Masoumeh Dadashaliha

Gynecologist & obstetrics, Faculty Member of Medicine School, Qazvin University of Medical Science, Qazvin, Iran