Female and Male Obesity and IVF Outcome: Knowns and unknowns

Background: Obesity reduces fecundity in both males and fe-males. Although most reports show generally poorer outcomes of assisted reproduction for overweight or obese women, there are important discrepancies in the literature that have been re-viewed in this study.Materials and Methods: This study was conducted as a review of the texts. In the Study key words are considered by using databases Cochrane, PubMed / Medline, Embrace/Scopus, Pro-Quest from 2000 to 2019.Results: Obese women especially with abdominal fat distribution, have a lower chance of pregnancy following IVF, require higher dosage of gonadotropins. Although the possible effects of obesity on male reproductive potential have been less studied, it is clear that, obesity are associated with reduced ejaculate volume, sperm concentration and total sperm count. However, these findings are not always consistent. BMI is not the best measure to reflect body fat and does not account for racial and ethnic differences in body build nor higher BMI due to increased muscularity. A recent rand-omized trial for weight loss among obese infertile women did not show improved birth rates compared with prompt infertility treat-ment within 24 months of randomization. As suggested by studies using oocyte donation as a research model, it seems that the nega-tive impact of obesity affects both ovarian and uterine functions. Conclusion: Although most reports show generally poorer out-comes of assisted reproduction for overweight or obese women, there are important discrepancies in the literature. This may be due to observational studies using heterogeneous inclusion cri-teria and outcome measures. However, the precise mechanisms are still in need of further clarification.

کلیدواژه ها:

Obesity ، Female ، Male ، IVF ،