Antioxidant in Endometriosis Treatment

Background: The etiology and pathogenesis of endometrio-sis is controversial. there are many studies investigating the relationship between endometriosis and oxidative stress. Ap-optotic endometrial tissues in endometrial implants produces reactive oxygen metabolites as metabolic intermediate product. The increase of the production of reactive oxygen and nitro-gen species (RONS) known as free radicals or the reduction of antioxidants bioavailability trigger the oxidative stress leaving organisms more susceptible to oxidative damage. an overview to identify an association between antioxidative treatment and improvement of endometriosis symptoms.Materials and Methods: A literature search was conducted through Pubmed and ScienceDirect.Results: Antioxidants are a defense mechanism created by the body to neutralize ROS. Antioxidants can protect against the cell damage that free radicals cause, known as oxidative stress. Some of them that may be effective in endometriosis treatment are: Vitamin C is an effective antioxidant that acts directly with superoxide, OH radicals, and singlet oxygen. Vitamin E acts as a peroxyl radical scavenger, inhibiting the effect of free radi-cals by forming a tocopheryl radical. Resveratrol is a natural polyphenolic flavonoid synthesized by plants subsequent to ul-traviolet radiation that inhibits ROS production in monocytes, macrophages and lymphocytes also were found to affect cell proliferation and apoptosis by inhibiting the NF-KB. Melatonin is a main secretory product of the pineal gland synthesized from tryptophan that is both a powerful free-radicals scaven-ger and an antioxidant enzymes stimulator with potent anti-in-flammatory attributes. Xanthohumol is a polyphenol chalcone from hops that has antioxidative and anti-inflammatory effects are achieved by the inhibition of NF- kB signaling pathway. Epigallocatechin-3-gallate (EGCG) is the most abundant poly-phenol found in green tea acts by reducing OS via inhibition of angiogenesis through VEGF reduction. EGCG suppresses estrogen-stimulated activation, proliferation and VEGF expres-sion of endometrial cells. N-acetyl-l-cysteine (NAC) is a thiol antioxidant and the precursor of glutathione that is apart from its ability to protect against damage from both hydroperoxides and other alkylating agents. Activation of the immune system by increasing glutathione levels, it suppresses the activation of NF-Kb an important transcriptional factor. Omega-3 fatty ac-ids inhibit the release of inflammatory mediators like IL-8 and prostaglandins in human endometrial stromal cells (HESC).Conclusion: Antioxidative stress agents showed a significant inhibitory effect on different studied aspects of the development and progression of endometriosis

کلیدواژه ها:

Endometriosis ، Antioxidant ، Stressoxidative