Oxidative Stress Markers in Early Pregnancy loss: A Case-Control Study

سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 256

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شناسه ملی سند علمی:

RROYAN20_417

تاریخ نمایه سازی: 29 مهر 1398

چکیده مقاله:

Background: Evidence suggests that oxidative stress plays a role inthe pathophysiology of pregnancy complications in women. The present study was conducted to determine the lev-els of oxidative stress markers in early pregnancy loss and to compare the results with those in healthy pregnant women.Materials and Methods: A total of 32 women with early preg-nancy loss and 32 healthy women in the first trimester of preg-nancy and with similar demographic characteristics entered this study as the cases and controls. Serum levels of malondialde-hyde (MDA), total antioxidant capacity (TAC) and uric acid and bilirubin levels were determined in both groups. The data obtained werethen analyzedand compared between the groups using the independent-sample t-test and Mann-Whitney’s U-test.Results: The two groups were matching in terms of person-al-demographic characteristics includingmother’s age, fa-ther’s age, gravidity andbody mass index(BMI). MDA levels increased significantly in the women with spontaneous abor-tion compared to the healthy pregnant women (4.35 ± 1.47 vs. 3.42 ± 1.68 µM/L; P=0.026) and TAC decreased significantly in the cases compared to the healthy controls(552.34 ± 212.79 vs. 1003.23 ± 1168.68 U/ml; P=0.040). Uric acid and bilirubin levels did not differ between the groups.Conclusion: The results of this study provide further evidence on the effect of increased oxidative stress on the incidence of early spontaneous abortion in the first trimester of pregnancy. High serum MDA levels and low TAC during pregnancy were two risk factors for spontaneous abortion. The present findings support the hypothesis that oxidative stress plays a key role in the etiopathogenesis of spontaneous abortion. Further studies are required for assessing the preventive role of antioxidant therapy in this complication.

نویسندگان

P Janati Ataei

Department of Midwifery and Reproductive Health, School of Nurs-ing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran