Inflammatory Factors in Women with Polycystic Ovary Syndrome

Background: Polycystic ovary syndrome (PCOS) is a complex condition that usually affects young women and is known by ovulatory dysfunction and androgen excess. The factors that cause PCOS are multiple, such as; genetic, lifestyle mistakes, and their combinations. PCOS is considered as a mild and chronic inflammatory condition, as a result, inflammatory fac-tors are affected.Materials and Methods: A literature search was conducted through PubMed.Results: A low-grade chronic inflammation state is also found in most PCOS women and has been related to metabolic and ovarian abnormalities, including androgen excess secretion. Adipose tissue releases more than 50 cytokines, acute-phase proteins, and other inflammatory mediators, which have an au-tocrine, paracrine, or systemic function and proinflammatory or anti-inflammatory activities that change in PCOS. According to study increased in circulating level of leptin, Resistin, Visfatin, Chemerin, and RBP4. Furthermore decreased or unchanged level of Adiponectin and Omentin can be seen. On the other side in PCOS patient concentration of inflammatory factors lev-el are increased such as CRP, TNFa, IL17, IL18, IL1B, IL6 but IL10 is an anti-inflammatory factor so the level of it decreased in PCOS.Conclusion: In PCOS inflammatory factors are affected as a result it can be used to treat and influence this disorder by fur-ther studies.

کلیدواژه ها:

PCOS ، Inflammatory Factor ، Cytokines