Effect of Oxymetholone on Spermatogenic Indices in Rats

Background: Oxymetholone as an anabolic steroid used ex-tensively among athletes for muscle mass enhancing can lead to testicular malfunctions.Materials and Methods: Twenty-one adult male rats were randomly categorized into 3 groups; group 1 was served as a control and groups 2 and 3 received 5 and 10 mg/kg/PO of Ox-ymetholone daily, respectively. After 60 days, the testicles were harvested and spermiation index (SPI) and tubular differentia-tion index (TDI) were recorded. Results: The SPI and TDI indices exhibited significant declines in Oxymetholone-administered groups in comparison with con-trol group.Conclusion: Anabolic steroids abuse can lead to severe sper-matogenesis impairment.

کلیدواژه ها:

Seminiferous Tubules ، Oxymetholone ، Spermato-genesis ، Rat