Seminiferous Tubules Histoarchitecture Changes in Nandrolone Decanoate-Treated Male Rats
سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 368
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شناسه ملی سند علمی:
RROYAN20_299
تاریخ نمایه سازی: 29 مهر 1398
چکیده مقاله:
Background: Nandrolone Decanoate as an anabolic steroid is used for physique- and muscle mass-enhancing purposes by athletes. The misuse of this drug has irreparable consequences such as male infertility.Materials and Methods: Eighteen rats were randomly catego-rized into 3 groups; group 1 was served as a control and groups 2 and 3 received 3 and 6 mg/kg of Nandrolone Decanoate weekly through intra-muscular injections, respectively. After 8 weeks, the testicles were harvested and the seminiferous tu-bules histoarchitecture was analyzed.Results: The seminiferous tubules epithelium thickness in the Nandrolone Decanoate -receiving groups showed a significant decrease compared to the control group, while seminiferous tu-bules luminal diameter in the Nandrolone Decanoate -treated rats exhibited a significant increase compared to the control group. Conclusion: High doses of Nandrolone Decanoate can have negative effects on male reproductive system.
کلیدواژه ها:
نویسندگان
P Farzipoour
Department of Biology, Faculty of Sciences, Urmia University Urmia, Iran
V Nejati
Department of Biology, Faculty of Sciences, Urmia University Urmia, Iran
E Hosein Najd Gerami
Department of Biology, Faculty of Sciences, Urmia University Urmia, Iran
A Shalizar-Jalali
Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University Urmia, Iran