Effects of Zinc Nanoparticles on The Testis of Wistar Rats

Background: The purpose of this study was to investigate the effect of Zinc oxide nanoparticles on the reproductive system in the male Wistar s rat Materials and Methods: 50 male Wistar rats weighing 220±20 g were divided into 5 groups of 10, including control group, sham, 25 mg/kg Zno (IP),50 mg/kg Zno (IP), 100 mg/kg Zno (IP) for twice a week. All stages of the test were performed in 4 weeks. The testes were evaluated by optical microscopy after tissue preparation steps.Results: Histopathologic findings showed, zinc oxide nano-particles in the testis, reduced cell population dose-dependent, respectively. In the group receiving 50 mg/kg, 100 mg/kg zinc oxide nanoparticles edema, Hyperemia and vacuolar degenera-tion were observed.Conclusion: Due to these observations it could be exhibited that ZnO nanoparticles may have the potential to induce repro-ductive failure in Wistar rat.

کلیدواژه ها:

Zinc oxide ، Testis ، Rat ، Nanoparticle