Estimating of Total Trans Fatty Acid in Subcutaneous Adipose Tissue of Pregnant Women with PCOS and Non-PCOS Pregnant Women

Background: Polycystic ovary syndrome (PCOS) is a complex and heterogeneous endocrine disorder with well-established metabolic abnormalities. The increasing epidemic of PCOS has led to a great deal of interest in the function of adipose tissue (AT) and quality of AT seems involved in the pathogenesis of PCOS. Fatty acid composition of adipose tissue triacylglycer-ol’s (AT-TAG) partly reflect dietary fatty acid intake of about 2 years, especially for those which cannot synthesis endoge-nously like trans fatty acids. the distribution of tFA produced via partial hydrogenation of vegetable oils (mainly elaidic acid :t9) differs compared to ruminant derived tFA (mainly vaccenic acid;t11). Our study not only measured the trans FA percentage in Iranian mother abdominal AT but also we analyzed for the first time individual isomers of trans C18:1 in PCOS and non-PCOS women.Materials and Methods: Abdominal subcutaneous AT sam-ples from 13 PCOS were compared with 32 non–PCOS women who underwent cesarean section. The FA composition of each biopsy was measured using gas chromatography. Data with nor-mal and abnormal distribution were analyzed using t test and Mann–Whitney U test, respectively.Results: No significant differences were found with respect to age and body mass index before pregnancy and at delivery day among non-PCOS and PCOS. Total trans FA, C18:1 t9 and C18:2t were lower in PCOS than non-PCOS whereas C18:1 t11 and C18:1 t6 were unaltered (p < 0.05).Conclusion: While the most report of trans fatty acid of adipose tissue belong to Iranian men and women in 2008, our result in compare to other researchs show not increasing rate. Our data confirms lower industrial trans isomer in AT of PCOS mother which may regarding more attention on nutrition in this group.

کلیدواژه ها:

PCOS ، Adipose Tissue ، Trans Fatty Acid