The Impact of Chemotherapy and Radiotherapy on Pre-Pubertal Gonad

Gonadal toxicity account as one of the most common compli-cations through chemotherapy and radiotherapy of patients with malignancy. In this regard in spite of effective treatments and improving the survival rate of patients with cancer, decreasing the outcome of hypogonadism and gonadal toxicity is inevitable. Modern multidisciplinary treatments and new generations of chemotherapy agents are making gonadal toxic effects less than before. It is important to point that some chemotherapy agents may be use in other non-malignant diseases. In this way all of the patients should inform about the possibility of gonadal tox-icity prior their treatment.Sperm banking could be effective way for patients who are go-ing to confer with chemotherapy and radiotherapy. Because spermatogenesis is so sensitive to treatment modalities of ma-lignancies. Testosterone deficiency in males could be easily im-prove with testosterone replacement.Ovary is also sensitive to chemotherapy and radiotherapy mo-dalities. Storage of ovarian tissue could be feasible but the pos-sibility of pregnancy in future should be noted. Also uterine function could be damage by radiotherapy and chemotherapy. Cancer survival rates is increasing recent years. Although treatment modalities have outcomes and late effects, the most important of those effects is gonadal toxicity. Increasing the knowledge of patients about this effect and suggesting future plans for dealing with this challenge is of necessities.

کلیدواژه ها:

Chemotherapy ، Gonadal Toxicity ، Radiotherapy