Use of iPSC Derived Hepatocytes for Liver Genera-tion/Replacement

Terminal liver failure caused by acute liver toxicants or by cir-rhosis caused by alcohol, non-alcoholic steatohepatitis or viral infections, can only be treated with liver transplantation. How-ever, due to the short supply of organs, many patients cannot be transplanted. Therefore, other sources of cells are being evalu-ated, including hepatocytes from pluripotent stem cells (PSCs). Data will be presented demonstrating that hepatocytes (and endothelial cells) derived from PSCs can be contemplated for grafting in vivo in the setting of liver failure, or can be used to recreate liver tissue in vitro by recellularization of decellular-ized liver scaffolds.