A systematic review of interactions between traditional herbs used in diabetes with common anti-diabetic medications: A systematic review
سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 437
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شناسه ملی سند علمی:
AMSMED20_315
تاریخ نمایه سازی: 22 مهر 1398
چکیده مقاله:
Background and Objective: Diabetes mellitus is a common metabolic disorder in the endocrine system. The prevalence and incidence of diabetes mellitus is increasing dramatically across the world. The aim of the current study is to review interactions between traditional herbs used in diabetes with common anti-diabetic medications. Search Method: Electronic databases including PubMed, Scopus, and Cochrane library were explored by using the keywords diabetes or plant or herb and arthritis . Data were collected from the inception date to 2018 (July). Results from primary search were screened by two independent investigators. inclision criteria include:stydies evaluating herb/drug interaction relevent clinical and invivo studies , studies evaluating interaction between herb and antidiabetic drugs. exit criteria include: stydies which evaluate interaction between herbalmedicine used for diseases other than diabetes , studies evauted interaction pharamacological categories other than antidiabetics. Findings: Herbal medicines with potential of induction of hypoglycemia, including Panax ginseng Trigonella foenum-graecum, Momordica charantia, Arctium lappa, Allium sativum, Gymnema sylvestre and Plantago Psyllium seeds have interaction with specific antidiabetic drugs because of enhancing the probability of hypoglycemia. Ginkgo biloba can enhance the hepatic metabolic clearance rate of insulin. Aloe vera juice showed hypoglycemic effect while administered along with glibenclamide in patients with diabetes mellitus. Glycyrrhiza glabra extract reduced plasma level of tulbotamide mediated by increasing intragastric pH and suppressing gastric emptying rate. Conclusion: Herbal medicines with potential of induction of hypoglycemia possess interaction with chemical antidiabetic drugs due to raising the probability of hypoglycemia, stimulating or inhibiting the CYP isoenzymes which metabolizing antidiabetic drugs are considered as the main reason of herb/drug interactions. Pharmacokinetic herb/drug interactions can result in whether elevating drug metabolism and lowering the bioavailability and efficacy of such drugs or reducing drug metabolism and enhancing adverse events antidiabetic agents.
کلیدواژه ها:
نویسندگان
Mohammad mehdi gravandi
Students Research Committee, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran
Mohammad Hosein Farzae
Pharmaceutical Sciences Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran