Dietary amino acids and anthropometric indices: Tehran Lipid and Glucose Study

Background: Obesity is a major health problem. It has been indicated that serum concentrations of amino acids (AAs) is related to excess weight. The aim of this study was to determine the association between dietary intakes of AAs and prospective change of anthropometric indices. Methods: Analyses were conducted on the data of 4976 participants, aged 18-75 year in the framework of Tehran Lipid and Glucose Study, with a 3 year follow up from 2008-2011 to 2011-2014. Dietary intakes of AAs were collected at baseline using a food frequency questionnaire. Anthropometric data includes height, weight, waist and hip circumference were collected at baseline and follow up and three year changes in obesity indices were calculated. Multiple linear regression analysis adjusted for potential confounders used to evaluate the association between amino acid intake and obesity indices. Results: The mean ± SD of age and BMI of participants were 41.2±13.4 and 27.3±4.8, respectively, and 44.8% of them were men. The median (interquartile range) yearly changes in weight, waist circumference (WC), and body adiposity index (BAI) were 0.33(-0.33, 1.33) kg, 0.00(-1.00, 1.33) cm, and -0.12(-0.44, 0.30), respectively. A weak positive correlation between lysine and aspartic acid with higher weight change was observed, whereas a negative but weak association was observed for acidic AAs, cysteine and glutamic acid. Furthermore, a weak positive correlation was shown for alkaline AAs, lysine and valine with WC; however acidic AAs, tryptophan, cysteine, and glutamic acid were negatively associated with WC. Aromatic and acidic AAs also indicated a weak negative relation with 3-year changes in BAI. Conclusion: Our results suggested that certain dietary AAs have the potential to change anthropometric indices.

کلیدواژه ها:

amino acid ، weight change ، waist circumference ، body adiposity index