Genital Involvement In Pre-Pubertal Pediatric Population: A Rare Aspect of Crohn’s Disease
محل انتشار: مجله بین المللی کودکان، دوره: 4، شماره: 9
سال انتشار: 1395
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 261
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شناسه ملی سند علمی:
JR_INJPM-4-9_005
تاریخ نمایه سازی: 20 مهر 1398
چکیده مقاله:
Crohn’s disease is an inflammatory bowel disease (IBD), characterized by chronic intestinal inflammation that causes the loss of immune tolerance leading to bizarre inflammatory signals and disruption of mucosal barriers. Environmental triggers and interaction of genetic determinants also play an indispensible role. In this case report, we present a pre-pubertal girl with intermittent and refractory genital swelling. We emphasize that Crohn’s disease must be considered in the differential diagnosis of recurrent, non-tender, erythematous and edematous lesions of the genital area. We conclude with future directions for diagnosing and managing vulvar Crohn’s disease in pediatric population.
کلیدواژه ها:
Crohn’s disease (CD) ، Inflammatory Bowel Disease (IBD) ، Infliximab ، Tumor necrosis factor alpha (TNF-α) ، Vulvar swelling
نویسندگان
Qurratul Ann Warsi
University of California and San Francisco, Department of Epidemiology and Biostatistics, ۱۸۲۵ ۴th street, Mission Bay, San Francisco, CA ۹۴۱۵۴, USA.
Meghana Kunduru
State University of New York Medical University, Syracuse, NY ۱۳۲۰۲, USA.
Manoochehr Karjoo
SUNY Upstate Medical University
Mirza Beg
۴Associate Professor of Pediatrics, ivision of Pediatric Gastroenterology, Hepatology, and Nutrition, SUNY Upstate Medical University, ۷۵۰ East Adams Street, Syracuse, NY ۱۳۲۱۰, USA.