Refractory Ocular Behçet’s Disease; Outcome of Low Dose Infliximab
محل انتشار: فصلنامه تحقیقات روماتولوژی، دوره: 4، شماره: 2
سال انتشار: 1398
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 331
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شناسه ملی سند علمی:
JR_RHRE-4-2_006
تاریخ نمایه سازی: 16 مهر 1398
چکیده مقاله:
A 40-year-old woman had been suffering of many symptoms of Behçet’s disease (BD) since her childhood without being diagnosed. She had recurrent mouth ulcers and from the age of 21 vulva ulcers followed by loss of vision due to central retinitis and later also ankle arthritis. At the age of 31, uveitis due to BD was diagnosed. The fact that BD is often not recognized in Bangladesh explains the marked delay in her diagnosis. The initial central retinitis responded well to oral glucocorticoids, azathioprine and cyclosporine, but in the course of time she became refractory to these agents. Considering her financial constraints, low dose Infliximab (3mg/kg) was used resulting in a remarkable but temporal improvement, she came in remission by using 5mg/kg regimen with increased interval time. We summarize the treatment options for ocular involvement in BD patientsConclusions: In countries like Bangladesh diagnosis of Behçet’s disease can be delayed. Early cooperation of dermatologists and eye surgeons with rheumatologists is necessary. Most cases of resistant ocular BD can nowadays be successfully treated with anti TNF-agents. Promising results are published with other biologics for refractory and multi-resistant cases.
کلیدواژه ها:
نویسندگان
Nira Ferdous
Modern One Stop Arthritis Care and Research Center®(MOAC&RC®), Dhaka Department of Medicine, MH Samorita Hospital and Medical College
Md Islam
Modern One Stop Arthritis Care and Research Center®(MOAC&RC®), Dhaka, Department of Rheumatology, Bangabandhu Sheikh Mujib Medical University (BSMMU)
Farah Rahman
Modern One Stop Arthritis Care and Research Center®(MOAC&RC®), Dhaka
Zahedur Pannu
Bangladesh Eye Hospital, Dhaka,