The First CBC in Diagnosis of childhood acute lymphoblastic leukemia

Leukemias are the most common malignant disorders in children, and acute lymphoblastic leukemia is the most prevalent form of childhood leukemia. The first diagnostic test for leukemic patients requested by general physicians or pediatrics is the complete blood count (CBC). This study was conducted to evaluate the results of the first CBC of children suffering from leukemia.this was a descriptive cross-sectional study. Leukemic patients´ data admitted to pediatric hematology- oncology ward of Shohada Tajrish Hospital between 1981 and 2009 formed the basis for our study. Sample population included one-month-old to fourteen-year-old children diagnosed with acute lymphocytic leukemia. Those with diseases influencing CBC test were excluded from the study. First, CBC test of the patients were evaluated and analyzed by SPSS software.97 patients were collected. The mean age of the patients was 74.2±48.3 months, and 50.5% were female and 49.5% were male. Among the 97 patients, 90.7% had neutropenia, 89.7% had thrombocytopenia, 89.7% had anemia, 77.3% had pancytopenia. Leukocytosis was detected in 39%, blast was detected in 24.7%, eosinophilia was detected in 4.13%, and NRBC was detected in 3.1% of the participants. 3 patients (3.1%) were detected with normal CBC and 7 patients (7.2%) were detected with abnormality in one type of cell. There was a strong correlation between prognosis and RBC count, WBC count, lymphocyte count, platelet count, hemoglobin and hematocrit concentration and MCV level.this study showed that although a few patients with ALL may have normal CBC or a CBC with minor changes, diagnostic suspicion of ALL could be possible by careful checking of CBC. Furthermore, thisdiagnostic testis a simple, available, and reasonable test.

کلیدواژه ها:

ALL ، CBC ، childhood