Zataria multiflora Boiss inhibits muscarinic receptors of incubated tracheal smooth muscle with propranolol
محل انتشار: مجله گیاهان دارویی ابن سینا، دوره: 1، شماره: 1
سال انتشار: 1390
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 313
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شناسه ملی سند علمی:
JR_AJP-1-1_002
تاریخ نمایه سازی: 1 مهر 1398
چکیده مقاله:
Objective(s): In the present study, the effect of tissue incubation with propranolol on functional antagonism of Zataria multiflora Boiss (Z. multiflora) at muscarinic receptors of tracheal smooth muscle was examined. Materials and Methods: The effects of three concentrations of aqueous-ethanolic extract, 10 nM atropine, and saline on muscarinic receptors were tested on incubated tracheal smooth muscle with propranolol (n=5). Results: The EC50 of all concentration of the extract and atropine was significantly higher than that of saline. There was parallel right ward shift in concentration response curves obtained in the presence of all concentrations of the extract. There was not any significant difference in the maximum response and slope obtained in the presence of different concentrations of extract compared to saline. There was significant positive correlation between the concentrations and the values of EC50 (p<0.001). The value of (CR-1) obtained in the presence of highest concentration of the extract was significantly higher than that of atropine (p<0.05). Conclusion: These results indicated that functional antagonism of Z. multiflora at muscarinic receptors of tracheal smooth muscle was mainly due to b-adrenoceptor stimulatory effect of plant.
کلیدواژه ها:
نویسندگان
Zahra Jafari
Department of Physiology and Pharmaceutical Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad, I. R. Iran
Mohammad Hossein Boskabady
Department of Physiology and Pharmaceutical Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad, I. R. Iran
Iran Pouraboli
Department of Biology, School of Sciences, Shahid Bahonar University, Kerman, I. R. Iran
Beheshteh Babazade
Department of Physiology and Pharmaceutical Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad, I. R. Iran