Antidepressant-like effect of aqueous extract from Rosa damascena in mice
محل انتشار: مجله گیاهان دارویی ابن سینا، دوره: 1، شماره: 2
سال انتشار: 1390
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 329
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شناسه ملی سند علمی:
JR_AJP-1-2_006
تاریخ نمایه سازی: 1 مهر 1398
چکیده مقاله:
Objective: Rosa damascena mill L (R. damascena) is an ornamental plant that has several therapeutic (such as sedative and hypnotic) effects. It also heals depression, grief, nervous stress and tension. In the present study we evaluated antidepressant-like effect of R. damascena using forced swimming test (FST).
Material and Methods: Three doses of aqueous extract (15, 60 and 90 mg/kg) was injected intraperitoneally. After 30 min of injection, immobility and swimming times were measured and compared with control (negative control) and imipramine (positive control).
Results: The results showed that low dose (15mg/kg) of extract significantly increased swimming time and decreased immobility time. However, the two high doses of extract (60 and 90mg/kg) had no significant effect on these parameters.
Conclusion: These results proposed antidepressant-like effect of low concentration of aqueous extract of R. damascena.
کلیدواژه ها:
نویسندگان
Karim Dolati
Pharmacological Research Center of Medicinal Plants and Department of Pharmacology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, I. R. Iran
Hassan Rakhshandeh
Pharmacological Research Center of Medicinal Plants and Department of Pharmacology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, I. R. Iran
Mohammad Naser Shafei
Neuroscience Research Center and Department of Physiology, School of medicine, Mashhad University of Medical Sciences, Mashhad, I. R. Iran