Adriamycin-induced oxidative stress is prevented by mixed hydro-alcoholic extract of Nigella sativa and Curcuma longa in rat kidney
محل انتشار: مجله گیاهان دارویی ابن سینا، دوره: 6، شماره: 1
سال انتشار: 1395
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 311
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شناسه ملی سند علمی:
JR_AJP-6-1_009
تاریخ نمایه سازی: 1 مهر 1398
چکیده مقاله:
Objective: Inflammation and oxidative stress is considered to have a crucial role in induction of nephropathy. Curcuma longa (C. longa) and Nigella sativa (N. sativa) have anti-inflammatory and antioxidant effects. This study was designed to investigate the effect of mixed hydro-alcoholic extract of N.sativa and C. longa on the oxidative stress induced by Adriamycin (ADR) in rat kidney. Material and Method: The animals were divided into 6 groups: control (CO), ADR, Adriamycin+ Vitamin C (ADR+VIT C), C. longa extract+ Adriamycin (C.LE+ADR), N. sativa extract+ Adriamycin (N.SE+ADR) and C. longa extract+ N. sativa extract + Adriamycin (N.S+C.L+ADR). ADR (5mg/kg) was injected intravenously, whereas VITC (100mg/kg) and extract of C. longa (1000mg/kg) and N. sativa (200mg/kg) were administrated orally. Finally, the renal tissue, urine and blood samples were collected and submitted to measure of redox markers, osmolarity and renal index. Results: The renal content of total thiol and superoxide dismutase (SOD) activity significantly decreased and Malondialdehyde (MDA) concentration increased in Adriamycin group compared to control group. The renal content of total thiol and SOD activity significantly enhanced and MDA concentration reduced in treated-mixed extract of C. longa and N. sativa along with ADR group compared to ADR group. The mixed extract did not restore increased renal index percentage induced by ADR. There also was no significant difference in urine and serum osmolarity between the groups. Conclusion: hydro-alcoholic extracts of N.sativa and C.longa led to an improvement in ADR-induced oxidative stress and mixed administration of the extracts enhanced the aforementioned therapeutic effect.
کلیدواژه ها:
نویسندگان
Reza Mohebbati
Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Mohammad Naser Shafei
Neurocognitive Research Center and department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Mohammad Soukhtanloo
Department of Biochemistry, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Noema Mohammadian Roshan
Department of Pathology, Qaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
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