Healing effect of ointment containing Fumaria officinalis on cutaneous wounds in male rats

In this study, 60 Sprague Dawley male rats were used. After creating the cutaneous wound, the animals were randomly divided into four groups; untreated control, treatment with Eucerin ointment, treatment with 3% tetracycline ointment, treatment with 3% F. officinalis aqueous extract ointment (3 gr of F. officinalis aqueous extract +97 gr base ointment). At days 10, 20, and 30 after creating the wound, for histopathological and biochemical analysis of the cutaneous wound healing trend, a section was prepared from all dermal thicknesses. The data were analyzed using one-way ANOVA followed by Duncan post hoc test.Findings: In vitro, DPPH free radical scavenging test was carried out to examine the antioxidant effect of F. officinalis aqueous extract, which indicated similar antioxidant activity with butylated hydroxy toluene as a positive control. In vivo, at days 10, 20, and 30, F. officinalis aqueous extract ointment could significantly (p<0.05) decrease the level of the wound area, total cell, macrophage, lymphocyte, and neutrophil, and enhance the level of wound contracture, fibrocyte, hexuronic acid, hexosamine, and hydroxyproline as compared to the basal ointment and control groups. Conclusion: The acquired findings showed the cutaneous wound healing potential of F. officinalis aqueous extract ointment

کلیدواژه ها:

Fumaria officinalis ، aqueous extract ، cutaneous wound healing