Experimental study on Wistar rats: The Descurainia sophia ointment effectively cure induced cutaneous wound

Treatment of wounds by ethno medicinal plants which have fewer side effects than chemical drugs has been on the rise. In this experiment, we assessed cutaneous wound healing potential of Descurainia sophia aqueous extract ointment in male rats. Materials and Methods: In our study, after creating the cutaneous wound on the back of the rats, the animals were randomly divided into four groups, untreated control, treatment with Eucerin ointment, treatment with 3% tetracycline ointment, treatment with 3% D. sophia aqueous extract ointment. The groups were treated for 30 days. For histopathological and biochemical analysis of the cutaneous wound healing trend, a 3x3 cm section was prepared from all dermal thicknesses at days 10, 20, and 30. The data were analyzed using one-way ANOVA followed by Duncan post hoc test.Findings: The use of D. sophia aqueous extract ointment in the treatment groups led to significant reduce (p<0.05) in the levels of wound area, total cells, lymphocyte, neutrophil, macrophage, and significant increase (p<0.05) in the levels of wound contracture, hydroxyproline, hexosamine, fibrocyte, fibroblast, and the rate of fibrocyte to fibroblast as compared to the control and basal ointment groups. Conclusion: According to the results, D. sophia aqueous extract ointment can treat the cutaneous wound

کلیدواژه ها:

Descurainia sophia ، ointment ، wound healing potential.