Production of non-enzymatic biosensor based on cobalt oxide nanoparticles for detection of glucose by electrochemical method

In this work, a novel electrochemical biosensor was produced for the glucose recognition. Cobalt Oxide Nanoparticle (CoNPs) synthesized a two-step process with a hydrothermal method. The CoNPs were characterized by X-ray diffraction (XRD). Also, the size distributions of nanoparticles were determined by dynamic light scattering (DLS), that more than 90 percent in the size range of 58–100 nm. The electrochemical performance of the CoNPs electrode for detection of glucose was investigated by cyclic voltammetry (CV). CoNPs show high electrocatalytic activity toward glucose oxidation in alkaline medium and are used for non-enzymatic electrochemical detection of glucose. The biosensor also had a linear response to glucose in the range of 0.5-2.5 mM and a low detection limit of 1.3 μM glucose (S/N=3). Therefore, the sensor shows great promise for simple, sensitive, and quantitative detection and screening of glucose and real sample (glucose in the human serum). This novel structured electrode holds great promise for the development of biosensors and other electrochemical devices.

کلیدواژه ها:

Biosensor Glucose ، Cobalt Oxide Nanoparticle ، Non-enzymatic ، Glassy Carbon Electrode ، Cyclic Voltammetry ، Electrochemical