Synthesis of Novel Bioactive Candidates 4-Aryl-1H-indeno [1,2-d]pyrimidine-2,5-diones using {[HMIM]C(NO2)3} as a Dual Role Ionic Liquid Catalyst: An Experimental and Theoretical Evaluation of Their Corresponding Antioxidant Activities

An efficient one-pot multi-component reaction of 1,3-indanedione, arylaldehydes and urealeading to new series of 4-aryl-1H-indeno[1,2-d]pyrimidine-2,5-diones in the presence of acatalytic amount of 1-methylimidazolium trinitromethanide{[HMIM]C(NO2)3}, as a nanoionic liquid, at ambient temperature under solvent-free conditions is reported. Advantages ofthe present protocol are the operationally simple and simple work-up, good to excellentyields, short reaction times, dual catalytic activity and reusability of the described catalyst.Finally, considering the role of oxidative stress in the progress of many ailments, the synthesizedindenopyrimidine derivatives were screened for their corresponding anti-oxidant activities.Theoretical investigation of anti-oxidant activities of the target molecules were alsochecked out.